منابع مشابه
Antitumor activity of bisphosphonates.
Introduction Bone metastases are a major cause of morbidity for patients with many types of cancer including multiple myeloma, breast cancer, prostate cancer, and other solid tumors. The clinical complications of bone metastases include pain, fracture, spinal cord compression, and hypercalcemia of malignancy. Although there are important differences in the biology of bone metastases from differ...
متن کاملBisphosphonates: mechanisms of action.
T bisphosphonates have been known to chemists since the middle of the 19th century, when the first synthesis occurred in 1865 in Germany (1). Etidronate, the first bisphosphonate to be used to treat a human disease (2), was synthesized exactly 100 yr ago (3). Bisphosphonates were used in industry, mainly as corrosion inhibitors or as complexing agents in the textile, fertilizer, and oil industr...
متن کاملDisambiguating the bisphosphonates.
The bisphosphonates comprise a class of therapeutic agents that inhibit bone resorption and are frequently used in medicine in the treatment of among others osteoporosis, skeletal metastases from solid tumours, hypercalcaemia of malignancy, multiple myeloma and Paget’s disease [1]. First synthesised in 1865 in Germany, their use had been primarily industrial as these molecules proved to be powe...
متن کاملBisphosphonates for osteoarthritis
Synovitis and subchondral bone turnover are associated with pain in osteoarthritis. Bisphosphonates provide tools for investigating these pathogenic mechanisms and also may have therapeutic potential. Translating preclinical findings into new treatments for human osteoarthritis requires a critical appraisal and refinement of animal models, identification of those pathogenic mechanisms that are ...
متن کاملEsophageal Cancer and Bisphosphonates
Volume 2 | Issue 1 At the beginning of 2009, Dianne Wysowski of the US Food and Drug Administration summarized 23 reports of esophageal cancer following alendronate use [1]. Wysowski also noted that there had been 31 cases following alendronate use in Europe and Japan and ten cases in which other bisphosphonates had been reported as concomitant or suspect treatment. Median time from exposure to...
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ژورنال
عنوان ژورنال: Journal of Pain and Symptom Management
سال: 2019
ISSN: 0885-3924
DOI: 10.1016/j.jpainsymman.2019.01.017